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Sigma‑2 Receptor/Transmembrane Protein 97 in Pain Modulation: Tracing Historical Roots and Current Research
Veronica M Hong1,2, Avaneesh Rade1,2, Amulya Bhaskara1,2
1Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, United States.
None:
The sigma-2 receptor/transmembrane protein 97 (σ2R/TMEM97) has emerged as a promising target for treating various diseases, including chronic pain. This review explores the potential of σ2R/TMEM97 as a novel therapeutic target for chronic pain management, addressing the need for effective nonopioid alternatives. First, we provide a historical overview of σ2R/TMEM97 research, tracing its early discovery and investigations. Second, we provide a comprehensive review of current research on the role of σ2R/TMEM97 in pain modulation. Lastly, we discuss potential mechanisms of action for σ2R/TMEM97 in pain modulation by drawing insights from its known biological activities in other contexts. By synthesizing current knowledge of the role of σ2R/TMEM97 in pain modulation, this review identifies gaps in the current pain literature and encourages future research into this promising biological target.
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