Related Experiment Video
Updated: Sep 15, 2025
07:36
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
11.5K
Clinical factors associated with developmental delay in placental abruption
Eun Hui Joo1, Nari Kim1, Hyun Mee Ryu1
1Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea.
Frontiers in Medicine
|July 17, 2025
Summary
A longer interval between diagnosing placental abruption (PA) and delivery, and delivery before 32 weeks, significantly increased the risk of neonatal developmental delay (DD). Ultrasound findings were not associated with DD.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Medicine
- Developmental Pediatrics
Background:
- Placental abruption (PA) is a serious obstetric complication.
- Neonatal developmental delay (DD) is a significant concern in infants born after PA.
- Understanding risk factors for DD in this population is crucial.
Purpose of the Study:
- To investigate the association between clinical characteristics and neonatal developmental delay (DD) in women with placental abruption (PA).
- To identify risk factors for developmental delay in infants born following PA.
Main Methods:
- Retrospective review of singleton pregnancies with PA (2010-2021).
- Neuromotor development assessed using Bayley Scales and/or Gross Motor Function Measure.
- Comparison of clinical characteristics between infants with and without DD.
Main Results:
- Among 9,374 deliveries, 188 (2.0%) had PA, with 33 infants exhibiting DD.
- A longer diagnosis-to-delivery interval (aOR=9.82) and delivery before 32 weeks' gestation (aOR=19.65) were significantly associated with DD.
- Maternal demographics and prenatal ultrasound findings suggestive of PA were not significantly associated with DD.
Conclusions:
- Prolonged diagnosis-to-delivery interval and extreme prematurity are significant risk factors for DD in infants with PA.
- Ultrasound findings are limited in predicting DD in PA cases.
- Timely clinical decision-making is critical; further research on PA diagnostic strategies is needed.
Related Concept Videos
01:07Teratogenicity
2.8K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.8K
01:20Pathophysiology of Diabetes
1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K