Related Experiment Video

Updated: Sep 15, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

20.0K

Hippo/YAP signaling's multifaceted crosstalk in cancer

Jie Zhang1, Haipeng Wu1,2, Xinxin Ren3

  • 1Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, China.

Frontiers in Cell and Developmental Biology
|July 17, 2025
PubMed

Insights

The Hippo/yes-associated protein (YAP) pathway regulates organ size and is crucial in cancer. Its complex interactions with other signaling pathways influence tumor growth and metastasis, offering potential therapeutic targets.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Signaling

Background:

  • The Hippo/yes-associated protein (YAP) signaling pathway is a conserved regulator of organ size, influencing cell proliferation, differentiation, apoptosis, and regeneration.
  • Dysregulation of the Hippo/YAP pathway is a key driver in tumorigenesis, impacting various stages of cancer development.

Purpose of the Study:

  • To review the molecular mechanisms of Hippo/YAP signaling crosstalk with other pivotal pathways in cancer biology.
  • To explore the implications of these intricate regulatory networks on tumor initiation, progression, and metastasis.

Main Methods:

  • Literature review focusing on molecular mechanisms of signaling pathway interplay.
  • Analysis of Hippo/YAP interactions with NF-κB, Wnt/β-catenin, TGF-β, Hedgehog, and Notch pathways.
  • Examination of the role of these interactions in cancer development and progression.

Main Results:

  • Hippo/YAP signaling engages in extensive crosstalk with multiple pathways, forming complex regulatory networks.
  • This crosstalk contributes to the context-dependent influence of Hippo/YAP on tumor initiation, progression, and metastasis.
  • Specific pathway interactions, including with NF-κB, Wnt/β-catenin, TGF-β, Hedgehog, and Notch, are detailed.

Conclusions:

  • The intricate interplay between Hippo/YAP and other signaling pathways is critical in cancer biology.
  • Understanding these molecular mechanisms provides insights into tumor development and offers potential therapeutic strategies.
  • Targeting these crosstalk mechanisms may represent promising avenues for novel cancer therapies.
Keywords:
Hippo/YAP signalingcancercrosstalksignaling pathwaytherapeutic target

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