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Cutaneous Mucormycosis in a Patient With Cirrhosis: A Case Report

Haley Belt1, Margaret Kypreos1, An Lu1

  • 1Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, USA.

Journal of Investigative Medicine High Impact Case Reports
|July 17, 2025
PubMed

Insights

Global mucormycosis infections are increasing. This case report details the sixth instance of cutaneous mucormycosis in a cirrhosis patient, exploring potential nosocomial causes for this severe fungal infection.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Hepatology

Background:

  • Invasive mucormycosis (mucor) incidence is rising globally, linked to increased immunosuppressive therapies for cancer and autoimmune conditions.
  • Cirrhosis is a known risk factor for fungal infections, yet inciting factors for isolated cutaneous mucormycosis remain poorly understood.
  • Cutaneous mucormycosis carries a high mortality risk and is rarely documented in cirrhosis patients (only 5 cases prior to this report).

Purpose of the Study:

  • To present the sixth documented case of cutaneous mucormycosis in a patient with cirrhosis.
  • To investigate potential nosocomial etiologies contributing to the development of clinically significant cutaneous mucormycosis in this patient population.

Main Methods:

  • Case report presentation.
  • Review of patient history and clinical course.
  • Exploration of potential nosocomial exposures and risk factors.

Main Results:

  • This report details the sixth case of cutaneous mucormycosis in a patient with cirrhosis.
  • The study explores potential nosocomial factors that may have precipitated the infection's progression.

Conclusions:

  • Cutaneous mucormycosis is a rare but severe complication in cirrhosis patients.
  • Further investigation into nosocomial factors is crucial for understanding and preventing mucormycosis in immunocompromised individuals with liver disease.
Keywords:
dermatologyinfectious diseasepulmonary critical care

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