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Related Experiment Video

Updated: Sep 15, 2025

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

Extracorporeal Support Vascular Access: 3D Printing Custom Cannulas.

Andrew Zhang^1,2, Megha M Jacob^1,2, Auldynn J Chambers²

¹From the Extracorporeal Life Support Laboratory, Department of Surgery, University of Michigan, Ann Arbor, Michigan.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)

|July 17, 2025

Summary

This summary is machine-generated.

This study developed novel 3D-printed 6 Fr cannulas for extracorporeal life support (ECLS) in premature infants. These 3D-printed cannulas demonstrate suitable flow rates for neonatal ECLS applications.

Keywords:

3D printing ECMO cannulas extracorporeal life support extracorporeal membrane oxygenation premature infants pressure drop

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Last Updated: Sep 15, 2025

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

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Published on: September 27, 2019

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Published on: May 19, 2022

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

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Published on: March 27, 2017

Area of Science:

Biomedical Engineering
Medical Device Development
Pediatric Critical Care

Background:

Extracorporeal life support (ECLS) requires patient-specific vascular access cannulas.
Existing drainage cannulas are unsuitable for neonates weighing less than 1.5 kg.

Purpose of the Study:

To develop and evaluate a novel 6 Fr drainage cannula for ECLS in small patients using 3D printing.
To assess the performance of 3D-printed cannulas in vitro and in vivo.

Main Methods:

Cannulas were manufactured using stereolithography 3D printing (Form 3 and Form 3B printers).
In vitro testing involved 3% glycerol to measure drainage pressure and flow rates.
In vivo testing was conducted using an ECLS piglet model.

Main Results:

3D-printed cannulas demonstrated appropriate flow rates (~100 ml/kg/min) for neonatal ECLS.
In vitro tests showed favorable drainage pressures and maximum flow rates for both printer types.
In vivo testing in piglets confirmed functional blood flow rates at acceptable drainage pressures.

Conclusions:

3D-printed 6 Fr cannulas are a viable option for ECLS in premature infants.
The fabrication process is minimally complex, offering a promising solution for neonatal vascular access.
Further preclinical optimization using translational models is recommended.