Unlocking the Potential of Ynamide as a Promoter in Copper(II)-Catalyzed O-Glycosylation
Hanyang Sun1,2,3, Zixuan Liu1,4,3, Bin Bai1,4,3
1Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
Abstract:
A copper-catalyzed glycosylation strategy was devised, utilizing ynamide as a promoter. An extensive examination of substrate scope was performed, encompassing a diverse array of alcohols and carbohydrates, which revealed the method's remarkable tolerance toward functional groups. By isolating and analyzing intermediates, valuable insights into the glycosylation mechanism were gained. The glycosylation methods presented in this study demonstrate substantial potential for the formal total synthesis of natural glycosides.
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