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A model for involutional bone loss.

J F Aloia, A Vaswani, K Ellis

    The Journal of Laboratory and Clinical Medicine
    |December 1, 1985
    PubMed
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    This study found that total body calcium and bone mineral content in the radius and spine can identify women with crush fractures. However, vertebral crush fractures are not linked to preferential loss of spinal bone.

    Area of Science:

    • Osteoporosis and Bone Health
    • Gerontology
    • Medical Imaging

    Background:

    • Bone mass measurement is crucial for understanding age-related bone loss and fracture risk.
    • Osteoporosis, particularly in postmenopausal women, leads to increased fracture incidence, especially vertebral crush fractures.
    • Previous hypotheses suggested preferential spinal bone loss in women with vertebral crush fractures.

    Purpose of the Study:

    • To assess bone mass in healthy men and women across different skeletal sites.
    • To evaluate the relationship between age and bone mineral content (BMC) in women.
    • To determine if vertebral crush fracture patients exhibit preferential spinal bone loss compared to controls.

    Main Methods:

    • In vivo neutron activation analysis for total skeletal bone mass.

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  • Single photon absorptiometry for distal radius bone mineral content (BMCr).
  • Dual photon absorptiometry for lumbar spine bone mineral content (BMCs) in women with and without vertebral crush fractures.

    • Main Results:

    • Bone loss rate was linear in men but showed a two-phase regression in women for total body calcium (TBCa), BMCr, and BMCs.
    • TBCa, BMCr, and BMCs were all effective in identifying women with crush fractures.
    • Ratios of BMCs/TBCa, BMCs/BMCr, and TBCa/BMCr did not differ between fracture patients and age-matched controls.

    Conclusions:

    • Total body calcium and bone mineral content at the radius and spine are useful indicators for identifying women with vertebral crush fractures.
    • The study's findings do not support the hypothesis of preferential spinal bone loss in women experiencing vertebral crush fractures.