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An Italian multidisciplinary Delphi Consensus on managing children and adolescents with acute fever using ketoprofen

Gianluigi Marseglia1,2, Michele Miraglia Del Giudice3, Francesco Scaglione4

  • 1Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

Minerva Pediatrics
|July 17, 2025
PubMed

Insights

Ketoprofen lysine salt (KLS) is effective for reducing pediatric fever, showing comparable efficacy and safety to acetaminophen and ibuprofen. Further research is recommended to solidify its role in fever management for children and adolescents.

Area of Science:

  • Pediatrics
  • Pharmacology
  • Clinical Immunology

Background:

  • Fever is a common symptom in children and adolescents.
  • Italian guidelines recommend fever treatment when discomfort is present.
  • Acetaminophen and ibuprofen are first-choice antipyretics, with ketoprofen lysine salt (KLS) also indicated for children aged 6+.

Purpose of the Study:

  • To propose practical statements on fever management in pediatrics.
  • To evaluate the potential use of ketoprofen lysine salt (KLS) for acute pediatric fever.
  • To reach a consensus among experts on KLS for fever relief.

Main Methods:

  • A multidisciplinary Delphi Consensus involving 33 experts.
  • Anonymous voting on statements drafted by a steering committee.
  • Discussion and consensus-building on fever management and KLS use.

Main Results:

  • Agreement on the physiological role of fever and the need to avoid indiscriminate reduction.
  • Consensus that KLS demonstrates comparable efficacy and safety to ibuprofen and acetaminophen in fever management.
  • Some expert disagreement regarding the speed of fever relief and specific safety aspects.

Conclusions:

  • Ketoprofen lysine salt (KLS) is a viable option for managing fever in pediatric patients.
  • Further methodologically robust comparative trials are needed to provide stronger evidence.
  • KLS efficacy and safety profile in children warrants continued investigation.

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