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3D-Bioprinted Scaffolds with Precise Factor Delivery for Spinal Cord Injury Repair.

Xia Cao^1,2, Xiaoli Li^1,2, Wenwan Shi^1,2

¹Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, People's Republic of China.

ACS Applied Materials & Interfaces

|July 17, 2025

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This summary is machine-generated.

This study developed a 3D-bioprinted scaffold for spinal cord injury (SCI) repair. The precision scaffold enhanced motor function recovery and nerve regeneration in rats.

Area of Science:

Biomaterials Science
Regenerative Medicine
Neuroscience

Background:

Spinal cord injury (SCI) causes permanent motor and sensory deficits.
Current treatments for SCI are limited, necessitating novel therapeutic strategies.

Purpose of the Study:

To develop a 3D-bioprinted scaffold for precise delivery of growth factors to promote SCI repair.
To investigate the efficacy of region-specific growth factors in supporting stem cell behavior and neural regeneration.

Main Methods:

Fabrication of a 3D-bioprinted scaffold with distinct hydrogels mimicking gray and white matter environments.
In vitro assessment of induced ectodermal mesenchymal stem cell (EMSC) proliferation and differentiation.
In vivo evaluation of the scaffold's impact on motor function recovery and neural regeneration in SCI rat models.

Keywords:

3D bioprinting EMSCs precise location regenerative medicine spinal cord injury

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Main Results:

Induced EMSCs showed enhanced proliferation and expansion within the scaffold's simulated gray and white matter regions.
The 3D-bioprinted scaffold significantly improved limb motor function recovery in SCI rats.
Scaffold implantation upregulated neuronal markers (GAP43, nestin, Tuj1) and downregulated glial scar marker (GFAP), indicating nerve regeneration.

Conclusions:

The 3D-bioprinted precision location scaffold effectively creates a regenerative microenvironment for SCI repair.
Region-specific growth factor delivery and induced EMSCs are crucial for promoting spinal cord regeneration.
3D bioprinting holds significant potential for neural tissue engineering and SCI treatment.