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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Papillary Neoplasms of the Breast: WHO Classification, Multimodality Imaging, and Radiologic-Pathologic Correlation.

Janice N Thai1, Jasmine Vickery1, Baris Boyraz1

  • 1From the Department of Radiology, Division of Breast Imaging (J.N.T., C.C., M.A.S.) and Department of Pathology (J.V., B.B., V.B.), Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (X.H.); Department of Pathology, Newton-Wellesley Hospital, Newton, Mass (V.V.M., M.A.T.); and Department of Pathology, Cleveland Clinic, Cleveland, Ohio (P.J.M.).

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This summary is machine-generated.

This review details the World Health Organization

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Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • The World Health Organization (WHO) classification system delineates five categories of papillary breast neoplasms.
  • These lesions exhibit papillary architecture with fibrovascular cores and range from benign to malignant.
  • Accurate diagnosis via core needle biopsy is challenging due to sampling limitations and overlapping features.

Purpose of the Study:

  • To provide an overview of papillary breast lesions and their WHO classification.
  • To describe clinical, imaging, and histopathologic features.
  • To highlight radiologic-pathologic correlation for improved clinical management.

Main Methods:

  • Review of the fifth edition of the WHO Classification of Breast Tumors.
  • Analysis of clinical, multimodality imaging, and histopathologic features.
  • Illustrative review of radiologic-pathologic correlation.

Main Results:

  • Papillary lesions are classified based on epithelial proliferation and myoepithelial cell presence.
  • Distinguishing noninvasive from invasive malignant forms is critical for prognosis and management.
  • A shift towards surveillance for benign intraductal papillomas without atypia is noted.

Conclusions:

  • Understanding the spectrum of papillary lesions and their WHO classification is essential.
  • Accurate radiologic-pathologic correlation aids in precise diagnosis and clinical decision-making.
  • Effective management strategies depend on distinguishing benign from malignant papillary neoplasms.