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Updated: Sep 15, 2025

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Carboxylic Acid Bioisosteres Boost Nurr1 Agonist Selectivity

Tanja Stiller1, Christian Gege2, Wael Saeb3

  • 1Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.

Journal of Medicinal Chemistry
|July 17, 2025
PubMed
Summary

Researchers developed a novel Nurr1 agonist, derived from vidofludimus, that selectively targets Nurr1 without inhibiting DHODH. This new compound shows potential for treating neurodegenerative diseases by promoting neuronal health.

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