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Patterns and Outcomes of Childhood Non-Infectious Uveitis: A Retrospective Cohort and Review of Literature

Raha Zamani1, Fatemeh Tahghighi Sharabian1,2, Alireza Zamani Khorasgani3

  • 1Department of Pediatrics, Tehran University of Medical Sciences, Children's Medical Center, Tehran, Iran.

Ocular Immunology and Inflammation
|July 17, 2025
PubMed

Insights

This study identified uveitis patterns in Iranian children, finding juvenile idiopathic arthritis (JIA) and Behçet's disease as common causes. Early onset and retinal vasculitis are risk factors for persistent pediatric uveitis.

Area of Science:

  • Ophthalmology
  • Pediatric Rheumatology
  • Immunology

Background:

  • Uveitis in children can lead to vision loss.
  • Understanding etiological patterns and risk factors is crucial for early intervention.

Purpose of the Study:

  • To identify patterns and risk factors of uveitis in Iranian children.
  • To analyze causes, subtypes, and complications of pediatric uveitis.

Main Methods:

  • Retrospective analysis of medical records from a tertiary pediatric rheumatology clinic.
  • Inclusion of juvenile-onset Behçet's disease and juvenile idiopathic arthritis (JIA) cases as controls.

Main Results:

  • Juvenile idiopathic arthritis (JIA) and Behçet's disease were leading causes of uveitis.
  • Anterior uveitis and panuveitis were most common; 28.8% had retinal vasculitis.
  • Lower age at onset and retinal vasculitis were risk factors for persistent/recurrent uveitis.

Conclusions:

  • Distinct uveitis patterns exist among etiological groups in pediatric patients.
  • JIA-associated uveitis shows a late-onset peak in the polyarticular group.
  • Long-term screening and early treatment are vital for pediatric rheumatic diseases with uveitis.
Abstract

Keywords:
Behçet’s diseaseJuvenile Idiopathic Arthritispediatric uveitissarcoid uveitisuveitis

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