Therapy for Stage IV Non-Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, Version 2025.1

Area of Science:

• Clinical Practice Guidelines
• Evidence-Based Medicine
• Oncology

Background:

• Clinical practice guidelines require frequent updates due to rapidly evolving evidence.
• Living guidelines are designed to address areas with fast-changing medical knowledge.
• The American Society of Clinical Oncology (ASCO) has established a methodology for developing and updating these guidelines.

Purpose of the Study:

• To describe the methodology and framework for ASCO Living Guidelines.
• To explain the process of continuous literature review and regular updates.
• To inform clinicians about the nature and limitations of living guidelines.

Main Methods:

• Systematic review of health literature on a continuous basis by a standing expert panel.
• Development following the ASCO Guidelines Methodology Manual.
• Adherence to the ASCO Conflict of Interest Policy for Clinical Practice Guidelines.

Main Results:

• Living guidelines are updated on a regular schedule to reflect the latest evidence.
• These guidelines are intended for specific topic areas with dynamic research.
• Updates are published regularly and accessible online.

Conclusions:

• Living guidelines offer a dynamic approach to clinical practice recommendations.
• They aim to keep clinicians informed about the most current evidence.
• These guidelines complement, rather than supersede, the treating clinician's professional judgment.