Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Cell Death

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...

Molecular Factors Affecting Cell Division

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...

Apoptosis

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...

The Cell Cycle Control System

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...

Cells Coordinate Growth and Proliferation

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development and non-clinical characterization of Procizumab (invobenitug): a humanized antibody neutralizing circulating DPP3.

mAbs·2026

Same author

Safety, tolerability, and pharmacokinetics/-dynamics of the dipeptidyl peptidase 3-inhibiting antibody Procizumab in a first-in-human trial.

mAbs·2026

Same author

The Hippo paradox: how growth suppression drives tumor growth.

EMBO reports·2026

Same author

AlphaFold3-based modeling uncovers the dynamic structural interface between full-length IAP antagonists and DIAP1 for apoptosis regulation in Drosophila.

Cell communication and signaling : CCS·2026

Same author

Calcium signaling regulates apoptosis-induced proliferation in Drosophila.

PLoS biology·2026

Same author

AlphaFold3-based modeling uncovers the dynamic structural interface between full-length IAP antagonists and DIAP1 for apoptosis regulation in <i>Drosophila</i>.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: Sep 15, 2025

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Cell Death, Compensatory Proliferation, and Cell Competition.

Andreas Bergmann¹

¹Department of Molecular, Cell and Cancer Biology, UMass Chan Medical School, Worcester, Massachusetts, USA;

Annual Review of Genetics

|July 17, 2025

Summary

This summary is machine-generated.

Cell death, compensatory proliferation, and cell competition are vital for tissue development and repair. These processes, involving apoptosis and cell competition, ensure tissue health and can be misregulated in diseases like cancer.

Keywords:

Drosophila apoptosis apoptosis-induced proliferation caspases cell competition compensatory proliferation

More Related Videos

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines

Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines

Published on: September 3, 2016

Related Experiment Videos

Last Updated: Sep 15, 2025

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines

Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines

Published on: September 3, 2016

Area of Science:

Developmental Biology
Cell Biology
Regenerative Medicine

Background:

Cell death (apoptosis), compensatory proliferation, and cell competition are fundamental processes in multicellular organisms.
These processes are crucial for tissue development, homeostasis, and regeneration.
Dysregulation of these pathways is implicated in various pathologies, including cancer.

Purpose of the Study:

To review the interconnectedness of cell death, compensatory proliferation, and cell competition.
To explore the history, examples, and molecular mechanisms of these fundamental biological processes.
To discuss the role of these processes in both normal physiology and disease states.

Main Methods:

Literature review synthesizing findings from diverse model organisms.
Analysis of molecular signaling pathways governing cell death, proliferation, and competition.
Comparative study across species including *Caenorhabditis elegans*, *Drosophila melanogaster*, and vertebrates.

Main Results:

Cell death eliminates damaged cells and can trigger compensatory proliferation.
Cell competition acts as a quality control mechanism, removing less fit cells.
Key molecular mechanisms underlying these processes are conserved across species.

Conclusions:

Cell death, compensatory proliferation, and cell competition are intricately linked and essential for tissue health.
Understanding these processes provides insights into development, regeneration, and disease.
Further research into their misregulation may reveal new therapeutic targets for conditions like cancer.