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Tick Microbiome Characterization by Next-Generation 16S rRNA Amplicon Sequencing
Published on: August 25, 2018
A pediatric case of cat scratch disease, complicated by meningitis, diagnosed by metagenomic next-generation
Li Jin1,2, Yang Wen3,2, Yiyuan Li3,2
1Department of Pediatric Infectious Diseases Nursing Unit, West China Second Hospital, Sichuan University, Sichuan, China.
Background:
Cat scratch disease (CSD) presents with diverse symptoms; however, meningitis as a complication is rare, and effective treatment strategies remain underexplored.
Case Presentation:
An 11-year-old girl presented with a prolonged fever of unknown origin, mild cough, and headache. Metagenomic next-generation sequencing (mNGS) identified Bartonella henselae in the bloodstream, and cerebrospinal fluid analysis confirmed meningitis. The patient was diagnosed with CSD complicated by meningitis and demonstrated a successful recovery following treatment with doxycycline, rifampicin, and prednisone.
Conclusions:
In CSD patients presenting with headaches and persistent fever, the possibility of meningitis should be considered. mNGS is a valuable diagnostic tool for CSD, especially in cases of fever of unknown origin. The combination of doxycycline, rifampicin, and prednisone proved effective in managing CSD with meningitis.
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