Related Experiment Video

Updated: Sep 15, 2025

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

8.5K

Differences between multi-triggered and single-triggered food anaphylaxis in children: a real life study

Şule Büyük Yaytokgil1,2, İlknur Külhaş Çelik1,3, Zeynep Şengül Emeksiz1

  • 1Department of Pediatric Allergy/Immunology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Türkiye.

The Turkish Journal of Pediatrics
|July 17, 2025
PubMed

Insights

Multi-triggered food-induced anaphylaxis (FIA) affects a quarter of children with FIA and is linked to atopy and higher IgE levels. Elevated IgE over 100 IU/mL predicts multiple food triggers in pediatric FIA.

Area of Science:

  • Pediatric Allergy and Immunology
  • Clinical Immunology
  • Food Allergy Research

Background:

  • Food-induced anaphylaxis (FIA) is a severe allergic reaction.
  • Limited data exists on multi-triggered FIA in children.
  • This study investigates differences between single and multi-triggered FIA.

Purpose of the Study:

  • To compare multi-triggered and single-triggered food anaphylaxis in pediatric patients.
  • To identify risk factors associated with multi-triggered FIA.

Main Methods:

  • Retrospective analysis of pediatric patients diagnosed with FIA.
  • Comparison of clinical characteristics between single-triggered and multi-triggered FIA groups.
  • Statistical analysis to identify predictive factors for multi-triggered FIA.

Main Results:

  • Approximately 25% of pediatric FIA cases were multi-triggered.
  • Multi-triggered FIA was associated with higher rates of atopic disease, asthma, and eosinophilia.
  • Elevated total IgE levels (>100 IU/mL) were a significant predictor of multi-triggered FIA (OR 2.46).

Conclusions:

  • Multi-triggered FIA is common in children and linked to allergic comorbidities.
  • Total IgE levels exceeding 100 IU/mL serve as a warning sign for multiple food triggers.
  • Clinicians should consider high IgE levels when screening and managing pediatric FIA patients.
Abstract

Keywords:
anaphylaxisfood induced anaphylaxismultiple triggeredsingle triggeredtotal IgE

More Related Videos

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

25.8K
Antigenic Liposomes for Generation of Disease-specific Antibodies10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.5K

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
28.8K
Cross-reactivity00:42

Cross-reactivity

Overview
31.5K
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
1.1K
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
981
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
2.2K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
606