Differences between multi-triggered and single-triggered food anaphylaxis in children: a real life study

Area of Science:

• Pediatric Allergy and Immunology
• Clinical Immunology
• Food Allergy Research

Background:

• Food-induced anaphylaxis (FIA) is a severe allergic reaction.
• Limited data exists on multi-triggered FIA in children.
• This study investigates differences between single and multi-triggered FIA.

Purpose of the Study:

• To compare multi-triggered and single-triggered food anaphylaxis in pediatric patients.
• To identify risk factors associated with multi-triggered FIA.

Main Methods:

• Retrospective analysis of pediatric patients diagnosed with FIA.
• Comparison of clinical characteristics between single-triggered and multi-triggered FIA groups.
• Statistical analysis to identify predictive factors for multi-triggered FIA.

Main Results:

• Approximately 25% of pediatric FIA cases were multi-triggered.
• Multi-triggered FIA was associated with higher rates of atopic disease, asthma, and eosinophilia.
• Elevated total IgE levels (>100 IU/mL) were a significant predictor of multi-triggered FIA (OR 2.46).

Conclusions:

• Multi-triggered FIA is common in children and linked to allergic comorbidities.
• Total IgE levels exceeding 100 IU/mL serve as a warning sign for multiple food triggers.
• Clinicians should consider high IgE levels when screening and managing pediatric FIA patients.