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Updated: Sep 15, 2025

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
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Fighting sarcomas at the root: The role of mesenchymal stem cells in sarcomagenesis

Margaux Chantoiseau1, Maria Eugénia Marques da Costa2, Birgit Geoerger2

  • 1INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif 94805, France.

European Journal of Cancer (Oxford, England : 1990)
|July 17, 2025
PubMed

Insights

Mesenchymal stem cells (MSCs) are crucial for tissue repair but can also drive cancer. Understanding their role in sarcoma development offers new therapeutic targets for cancer treatment.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Mesenchymal stem cells (MSCs) are multipotent cells vital for tissue development and regeneration.
  • MSCs are increasingly recognized for their dual role in both normal physiological processes and pathological conditions like cancer.

Purpose of the Study:

  • To review the physiological and pathophysiological roles of MSCs.
  • To explore the connection between MSCs and sarcoma development.
  • To identify potential therapeutic targets within the MSC-sarcoma axis.

Main Methods:

  • Literature review focusing on MSCs in mesenchymal tissues and sarcoma.
  • Analysis of MSC differentiation capabilities (osteogenic, chondrogenic, adipogenic).
  • Examination of MSC interactions within the tumor microenvironment.

Main Results:

  • MSCs contribute to skeletal growth, maintenance, and repair through lineage differentiation.
  • Within tumors, MSCs influence cancer cell growth, immune responses, and metastasis.
  • A strong link exists between MSCs and the cell of origin in sarcomas.

Conclusions:

  • MSCs possess both regenerative and oncogenic potential.
  • Understanding the MSC-sarcoma relationship is key to deciphering sarcoma origins.
  • Targeting MSCs offers promising avenues for novel sarcoma therapies.
Keywords:
CancersCell of originMesenchymal stem cellsPrecision medicineSarcomas

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