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Updated: Sep 15, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Efficient one-shot federated learning on medical data using knowledge distillation with image synthesis and client
Myeongkyun Kang1, Philip Chikontwe2, Soopil Kim1
1Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
This study introduces a novel one-shot federated learning (FL) method using mixup-generated synthetic images with noise. The approach reduces overfitting and computational costs in medical image classification tasks.
Area of Science:
- Artificial Intelligence
- Machine Learning
- Medical Imaging
Background:
- One-shot federated learning (FL) is crucial when multiple communication rounds are impractical.
- Existing knowledge distillation (KD) methods in one-shot FL struggle with overfitting and high computational demands.
- Medical image analysis requires efficient and accurate distributed learning models.
Purpose of the Study:
- To develop an efficient and robust one-shot federated learning framework for medical image classification.
- To address overfitting and reduce computational complexity in federated learning scenarios.
- To enhance knowledge transfer from clients to a global model using synthetic data.
Main Methods:
- Proposed a novel one-shot FL framework utilizing mixup for generating pseudo-intermediate samples with diverse structure noise.
- Implemented noise-adapted client models by updating batch normalization statistics to mitigate domain disparity.
- Employed iterative knowledge distillation (KD) between original and noise-adapted client models for global model updates.
Main Results:
- The proposed method significantly enhances training sample diversity, effectively preventing overfitting.
- Reusing synthesized images reduces computational resources and improves overall training efficiency.
- Extensive evaluations on multiple medical image classification datasets confirmed the approach's superiority over existing methods.
Conclusions:
- The novel one-shot FL framework effectively tackles overfitting and computational challenges in medical image classification.
- The use of mixup-generated noisy synthetic images enhances model robustness and training efficiency.
- The noise-adapted client models and KD strategy improve knowledge transfer and overall performance.
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