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Updated: Sep 15, 2025

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
Published on: June 26, 2016
Neurocosmetics are cosmetics, which mean that they could have effects only on skin
Laurent Misery1, Howard I Maibach2, John Koo2
1Department of Dermatology, University Hospital of Brest, Brest, France; Laboratory Interactions Nuerons-Keratinocytes, University of Western Brittany, Brest, France; European Society for Dermatology & Psychiatry, Innsbruck, Austria.
Abstract:
Neurocosmetics have been used since the 1990s and are defined as products that are supposed to modulate the neuro-immuno-cutaneous system functioning at the epidermal level. They have many potential applications, such as sensitive skin, skin stress, skin aging, pigmentation disorders, redness, skin regeneration, and skin inflammation. Cosmetics with pleasant properties are not neurocosmetics, and nothing new is being offered. Of more concern, some pseudo-neurocosmetics contain agonists and antagonists of neurotransmitters and, subsequently, potential effects on the central nervous system. These products are not cosmetics. There is an urgent need to inform patients, especially those with psychologic fragility.
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