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KRAS Mutation Status in Non-Small Cell Lung Cancer Distribution Across Occupational Categories.

Roberto Serna-Blasco1, Karla Medina2, María Ángeles Sala3

  • 1Department of Medical Oncology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, Madrid, Spain; Liquid Biopsy Laboratory, Department of Medical Oncology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, Madrid, Spain.

Chest
|July 17, 2025
PubMed
Summary
This summary is machine-generated.

Occupational exposures are linked to specific KRAS mutations in non-small cell lung cancer (NSCLC). Different jobs show varied KRAS mutation patterns, impacting lung cancer development.

Keywords:
KRASNSCLClung cancermolecular profilingoccupational exposuresmoking

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Area of Science:

  • Oncology
  • Molecular Biology
  • Occupational Health

Background:

  • Lung cancer is a leading cause of cancer mortality globally.
  • Occupational carcinogen exposure is a significant, yet understudied, factor in lung cancer etiology.
  • Understanding the molecular impact of occupational exposures is crucial for targeted prevention and treatment.

Purpose of the Study:

  • To investigate the association between occupational carcinogen exposure and the molecular profile of metastatic non-small cell lung cancer (NSCLC).
  • To identify specific occupations linked to distinct KRAS mutation prevalence and subtypes in NSCLC patients.

Main Methods:

  • Analysis of 302 metastatic NSCLC patients without EGFR/ALK mutations.
  • Detailed occupational histories classified using ISCO, Adapted Classification (AC), and IARCC.
  • Next-generation sequencing of tumor biopsy specimens to identify KRAS mutations.
  • Statistical comparisons between occupational groups and the overall cohort.

Main Results:

  • Higher KRAS mutation prevalence observed in cooks, painters, Personal Service Workers, and Building and Related Trades Workers.
  • Lower KRAS mutation frequencies noted in office workers and those with low/no exposure.
  • Distinct KRAS mutation subtypes identified across occupations, including G12C in Personal Service Workers, G12A in painters, and G12D in chemically exposed workers.

Conclusions:

  • Occupational exposures are significantly associated with specific KRAS mutation prevalence in NSCLC.
  • Different job categories exhibit unique KRAS mutation patterns, highlighting the role of occupation in lung cancer molecular pathogenesis.
  • Findings underscore the importance of considering occupational history in NSCLC research and clinical practice.