Related Experiment Video

Updated: Sep 15, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.0K

Plasma complement proteins as biomarkers and therapeutic targets in chronic kidney disease: a Mendelian randomization

Yu-Peng Xu1,2, Zheng-Qi Song2, Ming-Li Chen1

  • 1Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Wenzhou, Zhejiang, China.

Renal Failure
|July 17, 2025
PubMed

Insights

This study identifies specific plasma complement proteins as potential causal factors and biomarkers for Chronic Kidney Disease (CKD). These findings suggest new therapeutic targets for managing CKD and its progression.

Area of Science:

  • Immunology
  • Nephrology
  • Genetics

Background:

  • Chronic Kidney Disease (CKD) is a progressive condition with limited treatment options.
  • The complement system, a key immune network, is implicated in CKD pathogenesis.
  • Identifying reliable biomarkers for CKD onset and progression is crucial for effective management.

Purpose of the Study:

  • To investigate the causal role of plasma complement proteins in CKD and its clinical subtypes.
  • To discover novel biomarkers for CKD diagnosis and progression.
  • To identify potential therapeutic targets within the complement system for CKD.

Main Methods:

  • Utilized two-sample Mendelian randomization (MR) to analyze causal relationships.
  • Examined 28 plasma complement proteins against CKD outcomes using large-scale genetic datasets (FinnGen R11, CKDgen, 35,559 Icelandic individuals).
  • Performed protein-protein interaction and Gene Ontology (GO) enrichment analyses to explore biological pathways.

Main Results:

  • Identified 19 plasma complement proteins with causal links to CKD, with 6 remaining significant after correction.
  • CR1 and CFD showed significant associations with CKD risk and specific subtypes (membranous and diabetic nephropathy).
  • Complement proteins like CD55, C6, CR2, CFHR2, and CFD correlated with indicators of kidney function.

Conclusions:

  • Plasma complement proteins serve as promising biomarkers and therapeutic targets for CKD.
  • The study highlights the critical role of complement activation in CKD progression.
  • Findings support potential clinical applications in early CKD diagnosis, risk stratification, and treatment strategies.
Abstract

Keywords:
Chronic kidney diseaseMendelian randomizationkidney functionplasma complement

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

283
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

858

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
75
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
81
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
164
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
58
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
88
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
103