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Updated: Sep 15, 2025

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Hepatotoxicity induced by MK-677
Era Cobani1, Md Shahnoor Amin2, Muneer Hasso2
1Wayne State University School of Medicine, Detroit, Michigan, USA gh5767@wayne.edu.
Abstract:
MK-677, a growth hormone secretagogue, is gaining popularity among performance-enhancing supplements. While its side effects include oedema, increased appetite and muscle pain, reports of hepatotoxicity are scarce. Here we present the case of an otherwise healthy man in his early 30s, who developed transaminitis after consuming MK-677 for 2 months before presentation. Liver function tests eventually returned to normal limits after stopping the supplement.
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