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Related Experiment Video

Updated: Sep 15, 2025

Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection
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Supramaximal resection in primary brain tumors.

Vardhaan S Ambati1, Shawn L Hervey-Jumper1

  • 1Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.

Advances in Cancer Research
|July 17, 2025
PubMed
Summary

Supramaximal resection, an advanced surgical technique for brain tumors like gliomas, aims for maximal tumor removal while preserving neurological function. This extensive approach shows potential for improved survival and quality of life in patients.

Keywords:
Diffuse gliomaExtent of resectionGlioblastomaHigh-grade gliomaLow-grade glioma

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Area of Science:

  • Neurosurgery
  • Oncology
  • Neuro-oncology

Background:

  • Supramaximal resection is a key surgical principle for primary brain tumors, especially gliomas.
  • It extends beyond traditional gross total resection, aiming for maximal tumor removal while preserving neurological function.
  • Evidence suggests this extensive resection may improve survival without compromising quality of life.

Purpose of the Study:

  • To review the historical development and conceptual basis of supramaximal resection.
  • To present clinical data supporting the efficacy of supramaximal resection.
  • To describe modern techniques for safe and effective supramaximal resection.

Main Methods:

  • Review of historical data and clinical studies on supramaximal resection.
  • Description of intraoperative mapping techniques.
  • Discussion of functional preservation strategies.

Main Results:

  • Supramaximal resection may offer survival benefits.
  • This approach can be performed without compromising quality of life.
  • Modern techniques facilitate safe and effective implementation.

Conclusions:

  • Supramaximal resection is a promising surgical principle for brain tumors.
  • Further research and application of advanced techniques are encouraged.
  • This approach holds potential for improved patient outcomes in neuro-oncology.