Correlations between gut microbiota and serum metabolomics in patients with neurogenic rosacea

This study aimed to investigate the association between serum metabolomic profiles and the gut microbiota in patients with neurogenic rosacea. We analyzed the serum metabolites and gut microbial composition in 20 patients with neurogenic rosacea and 14 healthy controls. Metabolomic analysis identified 56 differentially abundant metabolites (DAMs), with benzene and substituted derivatives, carboxylic acids and derivatives, and organophosphates being among the most enriched categories. Gut microbiota analysis revealed significant dysbiosis in patients with neurogenic rosacea, characterized by an increased abundance of Lachnospiraceae, Veillonellaceae, and Clostridiaceae, and decreased levels of Prevotellaceae and Bifidobacteriaceae. Spearman's correlation analysis demonstrated significant relationships between specific serum metabolites and gut microbial taxa, including strong positive correlations between 3,4-dihydroxyphenylacetic acid and both Bifidobacterium (r = 0.7307, padj = 9.25e-07) and Lactobacillus (r = 0.6898, padj = 6.39e-06). These findings highlight the complex interactions between metabolic dysregulation and gut microbial imbalances in neurogenic rosacea, suggesting a potential role for the gut-skin axis in its pathophysiology. This study paves the way for future therapeutic strategies targeting both metabolic and microbial dysbiosis to manage neurogenic rosacea.