Tumor-associated mesenchymal stem/stromal cells in tumor microenvironment and carcinogenesis

Area of Science:

• Oncology
• Stem Cell Biology
• Regenerative Medicine

Background:

• Mesenchymal stem/stromal cells (MSCs) have therapeutic potential due to homing, differentiation, and immunomodulatory abilities.
• Tumors pose significant health risks with limited therapeutic options.
• MSCs' tumor-homing capacity is explored in cancer therapy, but their effects are complex.

Purpose of the Study:

• To review the existence, characteristics, and roles of tumor-associated MSCs (TA-MSCs) in solid tumors.
• To elucidate the mechanisms by which TA-MSCs influence tumor initiation and progression.
• To highlight the clinical implications of TA-MSCs in cancer management.

Main Methods:

• Literature review of studies on MSCs in solid tumors.
• Analysis of TA-MSCs' origin, heterogeneity, and interaction with tumor cells.
• Synthesis of evidence on TA-MSCs' contribution to the tumor microenvironment.

Main Results:

• TA-MSCs are distinct from normal MSCs and are integral components of the tumor stroma.
• TA-MSCs actively promote tumor progression through interactions with tumor cells and stromal elements.
• Evidence suggests TA-MSCs play a role in tumor initiation and development.

Conclusions:

• TA-MSCs represent a novel perspective for understanding malignancy.
• Further research into TA-MSCs is crucial for developing new cancer therapies.
• TA-MSCs hold potential for improving tumor diagnosis, prognosis prediction, and therapeutic strategies.