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Linking Cortical Structure and Cerebrospinal Fluid Metabolites with Venous Thromboembolism Risk: A Two-Step Mendelian
Tianni Liu1, Junxian Li2, Qiong Liu3
1First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Summary
This study explored brain structure and cerebrospinal fluid (CSF) metabolites for venous thromboembolism (VTE) risk. Lingual gyrus thickness showed a potential link, suggesting complementary roles for neuroimaging and CSF profiling in VTE risk assessment.
Area of Science:
- Neuroscience
- Metabolomics
- Vascular Biology
Background:
- Venous thromboembolism (VTE) is a complex vascular disorder.
- Neurovascular and metabolic factors are implicated in VTE pathogenesis.
- The roles of cortical structure and cerebrospinal fluid (CSF) metabolites in VTE risk are not well understood.
Purpose of the Study:
- To investigate the associations between cortical structure features, CSF metabolites, and VTE risk.
- To explore potential genetic pathways and mediatory effects using Mendelian randomization (MR).
Main Methods:
- Mendelian randomization (MR) analysis was used to examine associations.
- Mediation MR and co-localization analyses were employed to explore genetic pathways.
- Statistical correction (FDR) was applied to assess significance.
Main Results:
- MR analysis identified initial associations between cortical features, CSF metabolites, and VTE.
- Lingual gyrus thickness remained significantly associated with VTE after FDR correction.
- Suggestive associations were found for CSF metabolites isoleucine and methylmalonate.
- Mediation and co-localization analyses indicated distinct biological mechanisms for VTE risk.
Conclusions:
- Cortical structure features and CSF profiling may serve as complementary tools for VTE risk assessment.
- Distinct biological mechanisms likely underlie the influence of these traits on VTE.
- Further research is needed to elucidate the neurovascular and metabolic mechanisms of VTE.
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