Adherence to a Cholesterol-Lowering Diet and the Risk of Female Hormone-Related Cancers: An Analysis From a...

We investigated the association between a cholesterol-lowering diet score and the risk of female hormone-related cancers.

We used data on 2108 breast, 367 endometrial, 869 ovarian cancer cases and corresponding controls from an Italian network of case-control studies.

Hospital-based.

Breast, endometrial, and ovarian cancer cases and controls.

We assessed the adherence to a cholesterol-lowering diet using a score based on seven dietary components: high intake of non-cellulosic polysaccharides, monounsaturated fatty acids, legumes, seeds/corn oil; low intake of saturated fatty acids, dietary cholesterol, and glycaemic index. We assigned one point for each component if the requirement was met; otherwise, we assigned zero. The overall score was calculated by summing up points over the seven components, ranging from 0 (null) to 7 (complete adherence).

Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated through unconditional logistic regression models including terms for potential confounders.

Compared to a low adherence to a cholesterol-lowering diet (0-2 points), the ORs for a higher adherence (5-7 points) were 0.74 (95% CI: 0.60-0.92) for breast, 0.48 (95% CI: 0.30-0.77) for endometrial, and 0.77 (95% CI: 0.57-0.99) for ovarian cancer. The ORs for a 1-point increment in the score were 0.87 (95% CI: 0.97-0.80), 0.80 (95% CI: 0.72-0.90), and 0.90 (95% CI: 0.84-0.97) for breast, endometrial, and ovarian cancers, respectively.

A cholesterol-lowering diet may favourably affect the risk of female hormone-related cancers.