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Advances in Molecularly Imprinted Polymers for Bone Biomarker Detection and Therapeutic Applications
Ren Yang1,2, Xiaohan Ma1, Mingcheng Xuan3
1Division of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK.
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This review explores the application of molecularly imprinted polymers (MIPs) in detecting bone turnover biomarkers and advancing osteogenic treatment strategies. MIPs, designed to mimic biological recognition sites, offer innovative solutions for precise molecular recognition in bone health management. Chemical methodologies for MIPs synthesis and their integration into diagnostic systems for detecting bone resorption markers are highlighted. Furthermore, MIP-driven therapeutic advancements, including controlled drug release, cell imprinting for osteogenic differentiation, and functional scaffolds for tissue regeneration, are emphasized. This review underscores MIPs' potential to revolutionize bone disease management and calls for further exploration into chemical designs to optimize their clinical and practical applications.

