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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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Related Experiment Video

Updated: Sep 15, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

283

Complement Proteins Identify Rapidly Progressive Diabetic Kidney Disease.

Donghwan Yun1,2, Sohyun Bae1, Yuqian Gao3

  • 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Kidney International Reports
|July 18, 2025
PubMed
Summary
This summary is machine-generated.

Diabetic kidney disease (DKD) progression is linked to complement activation. A high urine complement score predicts faster DKD progression, suggesting complement inhibition as a therapeutic target.

Keywords:
biomarkerscomplement system proteinsdiabetic nephropathiespathologyproteomics

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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Assessment of Kidney Function in Mouse Models of Glomerular Disease
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Area of Science:

  • Nephrology
  • Proteomics
  • Immunology

Background:

  • Diabetic kidney disease (DKD) mechanisms are not fully understood.
  • Identifying biomarkers for DKD progression is crucial for effective treatment.

Purpose of the Study:

  • To identify urinary proteomic signatures associated with rapid DKD progression.
  • To investigate the role of complement activation in DKD pathogenesis.

Main Methods:

  • Untargeted and targeted mass spectrometry-based proteomics on urine samples from two independent cohorts (SNUH-DN and CRIC-T2D).
  • Analysis of urine proteins associated with kidney disease progression (doubling of serum creatinine, eGFR decline, or ESKD).
  • Development and validation of a complement score based on urine complement protein abundance.

Main Results:

  • Urinary proteins clustered into groups associated with disease progression risk.
  • A high complement score correlated with DKD histopathology and predicted a 2.4-fold higher hazard of progression.
  • Complement score effectively stratified patients into rapid and slow DKD progression groups in both cohorts.

Conclusions:

  • Complement activation is strongly associated with rapid DKD progression.
  • The urine complement score serves as a reliable biomarker for DKD progression.
  • Complement inhibition presents a promising therapeutic strategy for managing DKD.