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Biologic therapies offer new hope for severe asthma, improving lung function and reducing exacerbations. Achieving asthma remission requires personalized treatment selection and advanced biomarkers for better patient outcomes.

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Area of Science:

  • Pulmonology and Immunology
  • Pharmacology

Background:

  • Severe asthma impacts 5-10% of patients globally, causing significant morbidity and mortality.
  • Type 2 inflammation is a key pathway in severe asthma, targeted by emerging biologic therapies.

Purpose of the Study:

  • To review the efficacy and mechanisms of biologic therapies for severe asthma.
  • To explore strategies for achieving asthma remission, including biologics and complementary treatments.
  • To discuss optimizing treatment selection and future directions in severe asthma management.

Main Methods:

  • Review of current literature on biologic therapies for severe asthma.
  • Analysis of mechanisms of action, clinical efficacy, and limitations of available biologics.
  • Exploration of complementary strategies and emerging diagnostic tools for personalized treatment.

Main Results:

  • Biologics like omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab effectively reduce exacerbations and improve lung function in select patients.
  • Clinical remission rates with current biologics remain modest, highlighting the need for improved patient selection.
  • Complementary strategies and advanced biomarkers show promise for enhancing treatment precision and achieving sustained asthma control.

Conclusions:

  • Biologic therapies represent a significant advancement in managing severe asthma.
  • Personalized treatment approaches, guided by biomarkers and multiomics, are crucial for improving outcomes and achieving remission.
  • Further research into accessible point-of-care biomarkers is essential for advancing precision medicine in severe asthma.