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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

41
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
41
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

54
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
54
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

41
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
41
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

48
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
48
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

26
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
26
Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

51
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
51

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Updated: Sep 15, 2025

Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
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E. coli Pyogenic Ventriculitis: A Comprehensive Case Report.

Matthew A Hibdon1, Keri K Allen2, Alan Wang1

  • 1Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Clearwater, USA.

Cureus
|July 18, 2025
PubMed
Summary
This summary is machine-generated.

This case report details a rare instance of pyogenic ventriculitis caused by Escherichia coli (E. coli) originating from a sigmoid colon fistula. It highlights an atypical pathway to bacterial meningitis and ventriculitis in an immunocompromised patient.

Keywords:
e. coli bacteremiapelvic radiationsigmoidal fistulaventriculitisvertebral osteomyelitis

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Pyogenic ventriculitis is a rare complication of bacterial meningitis, often linked to compromised immunity or ventricular catheters.
  • Gram-negative organism involvement in ventriculitis is uncommon and typically associated with catheterization.

Observation:

  • A 48-year-old female with a history of cervical cancer and pelvic radiation presented with symptoms of meningitis and ventriculitis.
  • The patient had a sigmoid colon fistula leading to vertebral osteomyelitis and subsequent cerebrospinal fluid inoculation.
  • Escherichia coli (E. coli) was identified as the causative agent, leading to bacteremia.

Findings:

  • The case presents an unusual etiology of ventriculitis, not related to ventricular catheters.
  • Diagnostic findings and potential treatment strategies for this atypical presentation are discussed.
  • The patient's extensive comorbidities influenced the treatment decision towards supportive care despite E. coli bacteremia.

Implications:

  • This case underscores the importance of considering non-catheter-related causes of ventriculitis, especially in patients with specific risk factors.
  • It emphasizes the need for thorough investigation into potential sources of infection, such as gastrointestinal fistulas.
  • The report highlights challenges in managing rare infections in patients with significant comorbidities and discusses alternative therapeutic considerations.