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Updated: Sep 15, 2025
Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
Pilot study on photoacoustic imaging and confocal Raman spectroscopy-derived biomarkers for assessing structural and
Xiuting Li1, Yik Weng Yew2, Joshua Shou Yan Lim2
1A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, #07-01 Nanos, Singapore 138669, Singapore.
Abstract:
Atopic dermatitis (AD), a chronic inflammatory condition, is closely associated with obesity and type 2 diabetes mellitus (diabetes/DM). For the first time, using high-resolution photoacoustic imaging (PAI) and in-house-developed handheld confocal Raman spectroscopy (CRS), we studied in 35 subjects the dermal microvascular architecture, epidermal biochemical profiles and skin alterations in AD with DM and obesity. Utilizing the imaging-derived markers, we observed pronounced dermal hypervascularization in DM and obesity, worsening with AD, as reflected by altered oxygen saturation and epidermal biochemicals. Our findings highlight the role of non-invasive biophotonics techniques in assessing metabolic dysfunction during AD progression and management, underscoring their potential as promising non-invasive tools for real-time skin assessment.
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