Related Experiment Video

Updated: Sep 15, 2025

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Hypertrophic cardiomyopathy unveiling multiple myeloma: A diagnostic challenge

Lamassab Nour El Houda1,2, Bilal Marwa1,2, Noha El Ouafi3,1,2

  • 1Faculty of Medicine and Pharmacy, Mohammed Ist University, Oujda, Morocco.

Radiology Case Reports
|July 18, 2025
PubMed

Insights

Multiple myeloma, a blood cancer, can rarely cause hypertrophic cardiomyopathy and heart failure. This case highlights cardiac amyloidosis as an early sign of multiple myeloma before other symptoms appear.

Area of Science:

  • Hematology
  • Cardiology
  • Oncology

Background:

  • Hypertrophic cardiomyopathy is a complex cardiac condition.
  • Hematologic malignancies can rarely manifest with cardiac symptoms.

Observation:

  • A 65-year-old man presented with congestive heart failure.
  • Electrocardiogram (EKG) and echocardiography suggested cardiac amyloidosis.

Findings:

  • Etiological assessment revealed multiple myeloma as the underlying cause.
  • Cardiac amyloidosis secondary to multiple myeloma presented as new-onset, rapidly progressive heart failure.

Implications:

  • This case underscores the importance of considering multiple myeloma in patients with unexplained cardiac amyloidosis.
  • Early diagnosis of multiple myeloma is crucial for managing cardiac complications and improving patient outcomes.

Keywords:
Cardiac amyloidosisHypertrophic cardiomyopathyMultiple myeloma, Heart failure

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