Related Experiment Video

Updated: Sep 15, 2025

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

10.6K

Remarkable response to crizotinib in a patient with advanced lung adenocarcinoma harboring the MPRIP-ROS1 fusion

Yasuyuki Kishikawa1, Kohei Otsubo1, Daisuke Shibahara1

  • 1Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Respiratory Medicine Case Reports
|July 18, 2025
PubMed

Insights

This case study shows a rare MPRIP-ROS1 fusion in advanced non-small cell lung cancer (NSCLC). Crizotinib demonstrated significant tumor response, highlighting targeted therapy potential for rare fusions.

Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Background:

  • Genetic testing is vital for advanced non-small cell lung cancer (NSCLC) to identify targetable driver alterations.
  • ROS1-tyrosine kinase inhibitors (TKIs) are effective for common ROS1 fusions, but rare fusion partners' impact remains unclear.

Observation:

  • A 75-year-old female with advanced lung adenocarcinoma presented with an extremely rare MPRIP-ROS1 fusion.
  • The patient received crizotinib, a ROS1-TKI, for treatment.

Findings:

  • Despite dose reductions due to adverse effects, the patient achieved a significant tumor response to crizotinib.
  • The sustained efficacy of crizotinib, even at lower doses, was observed in this case of MPRIP-ROS1 fusion.

Implications:

  • This case suggests that targeted therapies like crizotinib may be effective for NSCLC harboring the MPRIP-ROS1 fusion.
  • Comprehensive genomic profiling, particularly hybrid capture-based next-generation sequencing, is crucial for detecting rare driver gene alterations in NSCLC.
Keywords:
Comprehensive genomic profilingCrizotinibMPRIP-ROS1 fusionNon-small cell lung cancer

More Related Videos

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction10:35

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

10.5K
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

18.1K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K