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Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection
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NKp30: A Key Membrane Molecule in the Fight Against Cancer and Infection

Yushu Shao1,2, Yang Zhang2, Jiaying Cao2

  • 1Department of Blood Transfusion, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|July 18, 2025
PubMed

Insights

Natural killer cells (NK) utilize the NKp30 receptor to identify and bind ligands, triggering cytotoxic activity. This review details NKp30 structure, function, and its role in fighting tumors and infections.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Natural killer (NK) cells are vital immune components.
  • NKp30 is a key activating receptor on NK cells.
  • NKp30 mediates NK cell cytotoxicity and immune responses.

Purpose of the Study:

  • To systematically review NKp30's structural features and functions.
  • To explore the influence of N-terminal glycosylation on NKp30 activity.
  • To elucidate the roles of NKp30 ligands in antitumor and anti-infection processes.

Main Methods:

  • Literature review and systematic summarization.
  • Analysis of structural and functional data.
  • Integration of findings on NKp30-ligand interactions.

Main Results:

  • NKp30 structure and basic functions are detailed.
  • N-terminal glycosylation significantly impacts NKp30 function.
  • NKp30 ligands and their mechanisms in immunity are identified.

Conclusions:

  • NKp30 plays a critical role in antitumor and anti-infective immunity.
  • Understanding NKp30 provides insights into immune regulation.
  • This review offers a comprehensive perspective on NKp30's multifaceted roles.
Keywords:
NKp30antitumoranti‐infectionmechanismsnatural killer cell

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