Related Experiment Video
Updated: Sep 15, 2025

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
Published on: May 23, 2025
Clinical outcomes of cyclophosphamide therapy in relentless placoid choroiditis: A descriptive case series
Miguel Pedroza-Seres1, Carlos E Rodríguez-López2
1Department of Uveitis and Ocular Immunology, Instituto de Oftalmología FAP Conde de Valenciana, Mexico City, Mexico.
Purpose:
To describe the clinical presentation and visual outcomes of relentless placoid choroiditis (RPC) in four patients treated with intravenous cyclophosphamide, a treatment not extensively studied in this condition.
Background:
RPC is a rare and recently described ocular disease characterized by a prolonged and progressive clinical course, widespread lesions, and unknown etiology. There is no consensus on its treatment, and the use of cyclophosphamide in RPC has not been extensively studied.
Case Presentation:
Four RPC patients treated with intravenous cyclophosphamide showed significant visual improvement (mean best-corrected visual acuity [BCVA] improved from 20/125 to 20/32) with minimal side effects.
Conclusion:
This case series demonstrates favorable outcomes with intravenous cyclophosphamide in RPC, supporting its potential as a safe, effective, and cost-efficient treatment option.
Related Concept Videos
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Chronic Pancreatitis II: Collaborative Care
Assessment:
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Chronic Kidney Disease II: Clinical Manifestations

