Osteosarcopenia, sarcopenia, and their associations with validated recent fragility fractures in older women: applying seven definitions in the FRISBEE 2 study
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View abstract on PubMed
Summary
This summary is machine-generated.Recent fractures in older women are linked to probable sarcopenia, specifically low handgrip strength. This finding suggests that a recent major osteoporotic fracture may indicate underlying sarcopenia, warranting further investigation into muscle strength as a modifiable risk factor.
Area Of Science
- Gerontology
- Bone and Muscle Health
- Epidemiology
Background
- Osteoporosis and sarcopenia are common in older adults, increasing fracture risk.
- Osteosarcopenia, the coexistence of both conditions, may further elevate this risk.
- Understanding the relationship between these conditions and recent fractures is crucial for prevention.
Purpose Of The Study
- To assess the associations between osteosarcopenia, sarcopenia (using seven definitions), and recent osteoporotic fractures in community-dwelling older women.
- To identify specific sarcopenia definitions that are most predictive of recent fractures.
Main Methods
- Retrospective cohort study of 907 women aged 77 years from the FRISBEE2 study.
- Sarcopenia, osteoporosis, and osteosarcopenia were assessed at baseline using various definitions.
- Recent central or major osteoporotic fractures (MOFs) were radiologically validated.
Main Results
- Prevalence of osteosarcopenia and sarcopenia varied significantly by definition.
- 47 (5.2%) women had experienced a recent fracture.
- Multivariate analysis revealed EWGSOP2-defined probable sarcopenia (low handgrip strength) was significantly associated with recent fractures (OR=2.14).
Conclusions
- Older women with recent fractures were more likely to have EWGSOP2-defined probable sarcopenia (low handgrip strength).
- A recent central or MOF should prompt screening for probable sarcopenia.
- Muscle strength may be a modifiable risk factor for fractures, requiring further prospective research.
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