Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Role of Fetal Laryngoscopy in Prenatal Counseling for Fetuses With Congenital High Airway Obstruction Syndrome: A Case Report and Review of the Literature.

The journal of obstetrics and gynaecology research·2026

Same author

Placenta Accreta Spectrum Risk in Endometriosis: A Retrospective Cohort Study with ART Subanalysis.

Journal of clinical medicine·2026

Same author

Mediating effect of social determinants of health between race and phthalate biomarkers in pregnancy.

Pregnancy (Hoboken, N.J.)·2026

Same author

Importance of placental evaluation in pregnancies at high risk for placenta accreta spectrum: Expert clinical perspective.

Pregnancy (Hoboken, N.J.)·2026

Same author

Controversies in fetal therapy.

Best practice & research. Clinical obstetrics & gynaecology·2026

Same author

Current Use and Barriers to POCUS in Women's Health: A National Survey of Veterans Affairs Medical Centers.

POCUS journal·2026

Same journal

Error in Grant Number in Funding/Support Section.

JAMA network open·2026

Same journal

The Supplementary Role of Friends in Caregiving Networks.

JAMA network open·2026

Same journal

Urbanicity, Neighborhood Conditions, and Dementia Mortality.

JAMA network open·2026

Same journal

Equity and Cancer Survival Among Veterans Health Administration Patients: A Systematic Review and Meta-Analysis.

JAMA network open·2026

Same journal

Limbic System Microstructure in Neonates With Antenatal Opioid Exposure.

JAMA network open·2026

Same journal

Risk and Protective Factors for Suicide Mortality in Youths: A Systematic Review and Meta-Analysis.

JAMA network open·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 8, 2025

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

Guidelines on Placenta Accreta Spectrum Disorders: A Systematic Review.

Giulia Bonanni^1,2, Maria C Lopez-Giron³, Lisa Allen^4,5

¹Fetal Care and Surgery Center, Division of Fetal Medicine and Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

JAMA Network Open

|July 18, 2025

Summary

This summary is machine-generated.

Clinical practice guidelines for placenta accreta spectrum (PAS) show consensus on diagnosis and antenatal management but lack guidance on cesarean hysterectomy and conservative treatments, highlighting a need for more research.

More Related Videos

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Published on: September 5, 2011

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Related Experiment Videos

Last Updated: Sep 8, 2025

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Published on: September 5, 2011

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Area of Science:

Obstetrics and Gynecology
Maternal-Fetal Medicine
Surgical Specialties

Background:

Placenta accreta spectrum (PAS) is a life-threatening obstetric complication requiring multidisciplinary management.
Standardized protocols and consensus are crucial for optimizing outcomes and mitigating risks in PAS.
Effective management necessitates collaboration among obstetrics, maternal-fetal medicine, and surgical/medical specialists.

Purpose of the Study:

To systematically review clinical practice guidelines for PAS.
To identify areas of consensus and gaps in guidance for PAS management.
To include guidelines from both high-income and low- to middle-income countries (LMICs).

Main Methods:

A comprehensive search of PubMed, GIN Library, and ECRI Guidelines Trust was conducted for PAS guidelines (2014-2024).
Two independent reviewers screened guidelines, with conflicts resolved by expert panel consensus.
Agreement scores were categorized as high agreement (≥75%), poor consensus (<50%), or high insufficient evidence (≥50%).

Main Results:

Fourteen guidelines were included, showing high agreement on specialized expertise, antenatal management, diagnosis, and epidemiology.
Poor consensus and insufficient evidence were found in cesarean hysterectomy, conservative techniques, and fertility counseling.
Significant gaps exist in recommendations for hemorrhage management, postnatal care, iron supplementation, and thromboembolism prevention, with limited focus on LMICs.

Conclusions:

Significant discrepancies and insufficient evidence exist in current PAS clinical practice guidelines.
There is an urgent need for further research and quality measures to standardize PAS care and improve patient outcomes.
Tailored guidance for LMICs is critical, addressing resource constraints and unique clinical access challenges.