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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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Related Experiment Video

Updated: Sep 14, 2025

Author Spotlight: Unraveling the Mechanobiology of Tendon Impingement – A Multiaxial Murine Hind Limb Explant Model
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Thyroid Achilles tendinopathy.

Xin Feng1, De-An Qin2, Hong-Xia Zhang3

  • 1Department of Orthopedics, Meihe Hospital of the First Hospital of Jilin University, Changchun, China.

International Journal of Surgery (London, England)
|July 18, 2025
PubMed
Summary
This summary is machine-generated.

Achilles tendinopathy may signal underlying thyroid issues like hypothyroidism or Hashimoto's thyroiditis. This condition is not just orthopedic but can indicate systemic metabolic problems, particularly in sedentary women.

Keywords:
Achilles tendinopathythyroid dysfunction

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Last Updated: Sep 14, 2025

Author Spotlight: Unraveling the Mechanobiology of Tendon Impingement – A Multiaxial Murine Hind Limb Explant Model
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Author Spotlight: Exploring the Complexities of Achilles Tendon Injuries — Research and Future Directions
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Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research
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Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

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Area of Science:

  • Endocrinology
  • Orthopedics
  • Rheumatology

Background:

  • Achilles tendinopathy (AT) is a complex condition with multifactorial causes and prolonged duration.
  • Extrinsic factors include mechanical overload and medication use.
  • Intrinsic factors encompass comorbidities like autoimmune inflammation, metabolic maladaptation, and endocrinopathies.

Purpose of the Study:

  • To investigate the role of intrinsic thyroid factors in the development of Achilles tendinopathy.
  • To propose the concept of "Thyroid Achilles tendinopathy."
  • To highlight AT as a potential sentinel symptom for subclinical thyroid dysfunction.

Main Methods:

  • Observational study analyzing intrinsic factors contributing to AT.
  • Clinical observation of patients presenting with AT.
  • Review of literature on comorbidities associated with AT.

Main Results:

  • Thyroid dysfunction, including asymptomatic hypothyroidism and Hashimoto's thyroiditis, is identified as a significant intrinsic factor in AT.
  • AT can serve as an early indicator of underlying thyroid disease.
  • The study suggests a link between AT and systemic dysmetabolic factors, especially thyroid dysfunction.

Conclusions:

  • Achilles tendinopathy should be considered beyond an orthopedic issue, particularly in sedentary middle-aged women.
  • Thyroid dysfunction is a crucial intrinsic factor to consider in the etiology of AT.
  • The concept of "Thyroid Achilles tendinopathy" warrants further investigation and clinical consideration.