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Related Concept Videos

Thoracic Aorta01:15

Thoracic Aorta

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The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
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Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

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Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Assessment of the Cardiovascular System I: Subjective Data01:23

Assessment of the Cardiovascular System I: Subjective Data

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A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
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Minimum Core Data Elements for Evaluation of Thoracic Aortic Disease.

Andreina Carbone1, Mary J Roman2, Melissa L Russo3

  • 1Department of Public Health, University of Naples "Federico II", Naples, Italy; Unit of Cardiology, University of Campania "Luigi Vanvitelli", Naples, Italy.

JACC. Advances
|July 18, 2025
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Summary
This summary is machine-generated.

This study identifies essential data elements for thoracic aortic disease (TAD) research. Standardizing data collection across registries will improve understanding of inherited aortic aneurysms and dissections.

Keywords:
aneurysmaortopathyclinical researchdissectionthoracic aortic disease

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Area of Science:

  • Cardiovascular Genetics
  • Medical Informatics
  • Rare Diseases

Background:

  • Thoracic aortic aneurysms (TAAD) and dissections are rare, heritable, and life-threatening conditions.
  • Understanding TAAD natural history and genetic factors necessitates international research collaboration.
  • Current TAD registries have significant data gaps hindering accurate, verifiable, and reproducible studies.

Purpose of the Study:

  • To define core data elements for thoracic aortic disease (TAD) research.
  • To develop standards for harmonizing data across TAD registries and clinical trials.
  • To establish a roadmap for future TAD research integrating clinical, genetic, and computational data.

Main Methods:

  • Analysis of data from ten contemporary TAD registries.
  • Expert panel review to identify critical data elements.
  • Assessment of data gaps in current research records.

Main Results:

  • Significant inconsistencies and gaps were found in data collected by TAD registries.
  • A recommended set of core data elements was identified.
  • Essential standards for data acquisition and computational modeling were proposed.

Conclusions:

  • Standardized data elements are crucial for advancing TAD research.
  • Future research should integrate precision clinical, genetic, and computational data.
  • Harmonized data protocols will facilitate collaborative studies and uncover new TAD phenotypes and risk factors.