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Articles linked to this work by shared authors, journal, and citation graph.

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Preterm birth as a risk factor for future maternal cardiovascular morbidity.

American journal of obstetrics & gynecology MFM·2026
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Modified multiple marker aneuploidy screening as a primary screening test for preeclampsia: A validation study.

Tianhua Huang1, Shamim Rashid2, Yanbo George Wang2

  • 1Genetics, North York General Hospital, Toronto, Ontario, Canada; Prenatal Screening Ontario, Better Outcomes Registry & Network (BORN) Ontario, Ottawa, Ontario, Canada; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada.

Pregnancy Hypertension
|July 18, 2025
PubMed
Summary

This study validates a preeclampsia screening algorithm using routine aneuploidy screening markers. The algorithm accurately predicts early-onset, preterm, and term preeclampsia, supporting its integration into standard obstetric care for early intervention.

Keywords:
First trimesterMaternal factorsPlacental growth factorPreeclampsiaPregnancy-associated plasma protein-APrenatal screening

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Biochemistry

Background:

  • Previous research indicated maternal characteristics, placental growth factor (PlGF), and pregnancy-associated plasma protein A (PAPP-A) can predict preeclampsia.
  • Routine aneuploidy screening offers an opportunity to integrate preeclampsia risk assessment.

Purpose of the Study:

  • To validate a preeclampsia screening algorithm in a large obstetric population using serum markers from routine aneuploidy screening.
  • To assess the algorithm's accuracy in predicting early-onset, preterm, and term preeclampsia.

Main Methods:

  • Retrospective cohort study of pregnant individuals undergoing enhanced first-trimester screening.
  • Analysis of maternal characteristics and serum markers (PlGF, PAPP-A) using logistic regression.
  • Comparison of marker multiples of the median (MoM) between preeclampsia cases and controls.

Main Results:

  • Preeclampsia cases showed significantly lower MoM for PlGF and PAPP-A compared to controls.
  • At a 20% false-positive rate, the algorithm predicted 80% of early-onset, 68% of preterm, and 58% of term preeclampsia.
  • The previously developed algorithm demonstrated comparable accuracy in this cohort.

Conclusions:

  • Findings support incorporating preeclampsia risk prediction into multiple marker aneuploidy screening.
  • This approach enables cost-effective, early identification of high-risk pregnancies for timely intervention.
  • Expansion of screening can improve maternal and fetal outcomes.