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A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
Published on: May 29, 2020
An allele of a hexameric enzyme is poised for an autoimmune dangerous mix
Di Wu1, Benjamin D Sheppard1, Adam D Steinbrenner1
1Department of Biology, University of Washington, Seattle, WA, USA.
Abstract:
In this issue of Molecular Cell, Wan et al.1 elucidate how incompatible genetic interactions between immune receptors and cellular homeostatic enzymes can lead to hybrid necrosis in the plant Arabidopsis thaliana. This suggests that the immune system can monitor cellular integrity via subtle structural changes in higher-order enzyme complexes.
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