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Published on: September 11, 2015
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Biomaterial multiscale geometry for regenerative immunoengineering of bone tissue.
Indra Mooij1, Iulian Apachitei1, Amir A Zadpoor1
1Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands.
Acta Biomaterialia
|July 18, 2025
Summary
Biomaterial surface geometry influences osteoimmunomodulation (OIM) by guiding immune cell and bone cell interactions. This review explores geometry-induced OIM (G-OIM) across scales, emphasizing coculture models for better orthopedic implant development.
Area of Science:
- Biomaterials Science
- Immunology
- Regenerative Medicine
Background:
- Osteoimmunomodulation (OIM) is crucial for orthopedic implant success.
- Biomaterial surface geometry significantly impacts cell interactions at the bone-implant interface.
- Understanding geometry-induced OIM (G-OIM) is key for enhancing osseointegration.
Purpose of the Study:
- To review advancements in geometry-induced OIM (G-OIM) across various length scales.
- To identify relationships between specific surface geometries and OIM mechanisms.
- To highlight the importance of coculture models in studying G-OIM.
Main Methods:
- Literature review of studies on geometry-induced OIM.
- Analysis of G-OIM across nano to mesoscale topographies and 3D scaffolds.
- Evaluation of coculture models for assessing macrophage-osteoprogenitor interactions.
Main Results:
- Specific surface geometries at different length scales demonstrate OIM potential.
- Macrophage polarization (M1/M2) and signaling pathways are influenced by geometrical cues.
- Direct coculture models reveal critical interplay between cells and biomaterials for OIM.
Conclusions:
- Geometry-induced OIM is a rapidly advancing field with significant potential for orthopedic implants.
- Improved coculture models using human cells are needed for clinical translation.
- Further development in biomaterial design and fabrication will advance G-OIM for regenerative immunoengineering.
