The role of heart-brain connectivity in neurodegeneration: Mechanisms and impacts
Muhammad Liaquat Raza1, Ghulam Kubra2, Ali Ammar3
1Department of Infection Prevention Control, Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia; King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.
Abstract:
Heart-brain connectivity is an emerging area of research, exploring the bidirectional communication between the cardiovascular and central nervous systems. This connectivity plays a significant role in neurodegenerative diseases, where both the heart and brain contribute to disease progression. This chapter shed light on the autonomic nervous system, neurocardiac interactions, and microvascular changes that are central to understanding how heart dysfunction can affect brain health. Pathophysiological processes such as inflammation, oxidative stress, and altered heart rate variability can exacerbate neurodegeneration, particularly in conditions like Alzheimer's and Parkinson's diseases. Understanding the heart-brain axis provides new avenues for early diagnosis and potential therapeutic strategies for neurodegenerative diseases. Future research should aim to unravel the complex interactions between these systems and explore how modifying cardiac function could influence brain health and disease progression.
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