Heart-brain synchrony: Therapeutic implications for neurodegenerative disease

Heart and brain functions are intricately connected. Previous research has explored the mechanisms behind the brain- heart axis and its clinical implications. Nonetheless, there is limited studies on the impact of heart disease on brain performance (heart-brain axis). In this context, hypoperfusion resulting from heart failure (HF) is considered a significant risk factor for cognitive impairment. Oxidative stress, immune responses, and blood perfusion contribute to cognitive dysfunction, playing a key role in this process. As such, it is important for healthcare professionals and researchers to consider the cognitive function of heart patients, particularly those having HF, to prevent the activation of this signaling pathway. Additionally, further investigation into the underlying mechanisms results in identifying new therapeutic targets for the treatment of cognitive dysfunction following heart disease. The current review aims to examine cognitive impairment in heart disease as well as its potential mechanisms, offering valuable insights for future research in related areas.