Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AhR inhibition promotes axon regeneration via a stress-growth switch.

Nature·2026
Same author

Novel Neurotrophin-3 peptidomimetic synthetic neurotrophin promotes neurological recovery after spinal cord injury.

Experimental neurology·2026
Same author

NX210c Demonstrates Therapeutic Potential to Restore Blood-Brain Barrier in a QSP Model of Relapsing-Remitting Multiple Sclerosis.

International journal of molecular sciences·2026
Same author

Leveraging microbiota-metabolites to reduce inflammation and promote functional recovery following spinal cord injury in female mice.

Brain, behavior, & immunity - health·2025
Same author

Interleukin-27 is antiviral against Zika virus at the maternal-fetal interface.

Nature communications·2025
Same author

Administration of a Novel Peptide Derived From Thrombospondin Repeat Sequences Enhances Recovery after Cervical Spinal Cord Injury.

Journal of neurotrauma·2025

Related Experiment Video

Updated: Jul 2, 2026

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
20:14

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

16.5K

SCO-Spondin-Derived Peptide NX210 Promotes Functional Recovery after Spinal Cord Injury in Mice.

Theresa C Sutherland1, Sighild Lemarchant2, Ashley J Douthitt1

  • 1Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, Bryan, Texas, USA.

Journal of Neurotrauma
|July 18, 2025
PubMed
Summary

NX210, a peptide analogue, significantly improved motor function and reduced pain after spinal cord injury (SCI) in mice. This therapeutic strategy shows promise for promoting repair and mitigating long-term impairments following SCI.

Keywords:
SCO-spondindorsal hemisectionmotor functionneuroprotectionpainrepairtherapeutics

More Related Videos

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
11:57

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

9.4K
Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats
08:46

Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats

Published on: March 24, 2020

15.5K

Related Experiment Videos

Last Updated: Jul 2, 2026

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
20:14

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

16.5K
Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
11:57

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

9.4K
Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats
08:46

Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats

Published on: March 24, 2020

15.5K

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Pharmacology

Background:

  • Spinal cord injury (SCI) causes irreversible impairments, impacting a growing patient population.
  • Current treatments for SCI are limited, necessitating novel therapeutic approaches.
  • Thrombospondin repeats peptide analogues are being investigated for their neuroprotective and regenerative potential.

Purpose of the Study:

  • To evaluate the therapeutic efficacy of NX210, a thrombospondin repeats peptide analogue, in a mouse model of SCI.
  • To assess the impact of NX210 on motor function, sensory processing, and neuropathological changes post-SCI.
  • To determine the optimal dosage and treatment regimen for NX210 in SCI recovery.

Main Methods:

  • A dorsal hemisection model of SCI was established in adult female mice.
  • Mice received intraperitoneal injections of NX210 at varying doses (4, 8, 16 mg/kg) starting 4 hours post-injury.
  • Functional recovery was assessed weekly for 10 weeks using the Basso Mouse Scale (BMS), rotarod, and activity chamber tests.
  • Immunohistochemistry was performed on spinal cord tissues to evaluate myelin basic protein, neuron/glial antigen 2, lesion size, inflammation, and neuron survival.

Main Results:

  • NX210 treatment led to significant improvements in hind limb motor function, including BMS scores and rotarod performance.
  • Locomotor activity and pain sensitivity (tail flick test) were positively modulated by NX210.
  • Histological analysis revealed increased myelin basic protein and reduced neuron/glial antigen 2 at the injury site.
  • No significant effects were observed on lesion size, overall inflammation, or neuron survival.

Conclusions:

  • NX210 demonstrates significant therapeutic potential for improving functional recovery after spinal cord injury.
  • The peptide analogue promotes myelin repair and modulates glial responses at the injury site.
  • NX210 represents a promising new strategy for mitigating long-lasting impairments associated with SCI.