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Updated: Sep 14, 2025

Immunolabelling Myofiber Degeneration in Muscle Biopsies
Published on: December 5, 2019
Advances in the Regulation by Immune Cells of Skeletal Myositis Outcomes
Shuxian Huang1,2, Yongling Zhao1,3, Yuanpeng Xin1,4
1Department of Laboratory Medicine, School of Medicine, Foshan University, Foshan, 528000, China.
Abstract:
Skeletal myositis prevalence is increasing annually, impairing mobility and potentially causing acute organ failure. Following muscle injury, various factors within damaged muscle trigger immune cell exudation from the bloodstream to the injured area, influencing disease progression. This paper synthesizes global research on cellular/molecular mechanisms in skeletal myositis, examining immune cell regulation in exogenous-induced skeletal myositis, dystrophic myopathy, and idiopathic inflammatory myopathy (IIM). We conclude that cytokines from intramuscular immune cells represent key targets for clinical management and therapeutic development.
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