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Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

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Healthy skin, Healthy brain.

Kyeong-No Yoon¹, Jin Ho Chung¹

¹Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University, Seoul, Korea; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.

Journal of Dermatological Science

|July 18, 2025

Summary

Skin aging impacts brain aging via the skin-brain axis. Protecting skin health may mitigate cognitive decline and enhance brain resilience.

Keywords:

BDNF Cognitive decline Cortisol Dopamine Inflammation Neuroendocrine signaling Skin–brain axis Tomato and lemon extracts UV radiation skin aging

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Area of Science:

Neuroendocrinology
Neuroimmunology
Dermatology

Background:

Skin aging affects brain aging through neuroendocrine, inflammatory, and neurochemical pathways.
The skin functions as a neuroendocrine organ communicating with the central nervous system (CNS).
The skin-brain axis describes this bidirectional communication, relevant to psychodermatology and neuroimmunology.

Purpose of the Study:

To review how extrinsic (e.g., UV radiation) and intrinsic aging disrupt skin homeostasis.
To highlight the systemic effects of skin aging on brain functions.
To explore interventions for preserving skin and brain health.

Main Methods:

Literature review of studies on skin aging, UV radiation, and brain function.
Analysis of mechanisms including the hypothalamic-pituitary-adrenal (HPA) axis, neurotransmitters, and brain-derived neurotrophic factor (BDNF).

Main Results:

Chronic UV exposure activates the cutaneous HPA axis, increases cortisol, and impairs hippocampal neurogenesis and cognition.
UV-induced neurotransmitter alterations affect learning, memory, and emotion.
Skin aging reduces skin BDNF synthesis, potentially contributing to cognitive decline.

Conclusions:

Skin aging is a significant factor in brain aging.
Interventions like sunscreens, moisturizers, and polyphenols may protect the skin-brain axis.
Maintaining skin health is a potential strategy for mitigating brain aging and enhancing cognitive resilience.