Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

207
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
207
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

25
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
25
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

241
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
241
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

122
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
122
Nursing Assessment of the Genitourinary System II: Inspection and Palpation01:26

Nursing Assessment of the Genitourinary System II: Inspection and Palpation

231
The nursing assessment of the genitourinary (GU) system involves a systematic inspection and palpation to identify abnormalities in the kidneys, bladder, and surrounding structures.InspectionMouth: Inspect for signs of kidney dysfunction, such as stomatitis (inflammation of the mouth) and ammonia breath, which may occur in advanced kidney disease due to the buildup of urea, breaking down into ammonia.Skin: Check for pallor, which could indicate anemia caused by kidney disease. Look for...
231
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

1.5K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human urinary extracellular vesicle preparations inhibit <i>in vitro</i> biofilm formation against several uropathogens.

Frontiers in microbiology·2026
Same author

A FRMDable Future for Fibrosis?

Kidney360·2024
Same author

Neutrophil extracellular traps protect the kidney from ascending infection and are required for a positive leukocyte dipstick test.

Science translational medicine·2024
Same author

HYDROchlorothiazide versus placebo to PROTECT polycystic kidney disease patients and improve their quality of life: study protocol and rationale for the HYDRO-PROTECT randomized controlled trial.

Trials·2024
Same author

Excretory-secretory products from the brown stomach worm, Teladorsagia circumcincta, exert antimicrobial activity in in vitro growth assays.

Parasites & vectors·2022
Same author

Point-of-care and self-testing for potassium: recent advances.

Sensors & diagnostics·2022

Related Experiment Video

Updated: Sep 14, 2025

Generation of Human Kidney Tubuloids from Tissue and Urine
08:34

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

5.0K

How to Suspect and Approach Patients With Genetic Tubular Disease.

Fiona E Karet Frankl1

  • 1Professor of Nephrology/Hon. Consultant in Renal Medicine, University of Cambridge, Cambridge, UK; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.

Seminars in Nephrology
|July 18, 2025
PubMed
Summary

Diagnosing rare inherited renal tubular disorders requires a comprehensive approach, including clinical evaluation and biochemical testing. Genetic testing can confirm diagnoses, improving patient quality of life.

Keywords:
Electrolytenephron segmenttransportertubulopathy

More Related Videos

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
08:09

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection

Published on: July 25, 2017

12.4K
Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format
05:58

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Published on: August 20, 2018

11.0K

Related Experiment Videos

Last Updated: Sep 14, 2025

Generation of Human Kidney Tubuloids from Tissue and Urine
08:34

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

5.0K
Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
08:09

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection

Published on: July 25, 2017

12.4K
Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format
05:58

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Published on: August 20, 2018

11.0K

Area of Science:

  • Nephrology
  • Genetics
  • Internal Medicine

Background:

  • Inherited renal tubular disorders (tubulopathies) are rare and can present with complex extrarenal features.
  • Diagnosis often involves a combination of patient history, clinical examination, biochemical analysis of blood and urine, and imaging.
  • Patients frequently experience diagnostic delays due to the rarity of these conditions.

Purpose of the Study:

  • To outline the diagnostic approach for inherited renal tubular disorders.
  • To emphasize the importance of biochemical assessment alongside genetic testing.
  • To highlight the potential for genetic confirmation to improve patient outcomes.

Main Methods:

  • Review of diagnostic strategies for inherited tubulopathies.
  • Integration of clinical, biochemical, and imaging data.
  • Role of genetic testing in confirming diagnoses.

Main Results:

  • A multi-faceted diagnostic process is essential for identifying rare renal tubular disorders.
  • Biochemical evaluation remains crucial, even with the availability of genetic testing.
  • Genetic confirmation can significantly enhance the quality of life for affected patients.

Conclusions:

  • Early and accurate diagnosis of inherited renal tubular disorders is critical.
  • A combination of clinical acumen, biochemical analysis, and genetic testing provides the most effective diagnostic pathway.
  • Improving diagnostic timelines through genetic confirmation can positively impact patient well-being.