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Addressing osteoblast senescence: Molecular pathways and the frontier of anti-ageing treatments

Zhengdong Zhang1,2,3, Pan Liu4, Yu Song1

  • 1Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Clinical and Translational Medicine
|July 18, 2025
PubMed
Abstract

Insights

Osteoblast senescence drives age-related osteoporosis by disrupting bone formation. Counteracting this process offers therapeutic potential for mitigating bone loss and treating osteoporosis.

Area of Science:

  • Gerontology
  • Cell Biology
  • Bone Biology

Background:

  • Osteoblast senescence is a primary contributor to age-related osteoporosis.
  • Counteracting osteoblast senescence can significantly reduce bone loss.
  • Understanding these mechanisms is crucial for developing effective osteoporosis treatments.

Purpose of the Study:

  • To review the hallmarks of osteoblast senescence.
  • To explore the signaling pathways involved in osteoblast senescence.
  • To summarize therapeutic strategies targeting osteoblast senescence for age-related osteoporosis.

Main Methods:

  • Review of current literature on osteoblast senescence and osteoporosis.
  • Analysis of signaling pathways, proteins, and genes modulating osteoblast senescence.
  • Examination of therapeutic strategies for preventing and treating osteoblast senescence.

Main Results:

  • Osteoblast senescence disrupts bone formation and homeostasis through pathways like telomere shortening and SASP secretion.
  • Age-related bone loss involves complex signaling pathway crosstalk.
  • Multiple therapeutic targets exist, but challenges remain in treatment.

Conclusions:

  • Osteoblast senescence is a critical factor in age-related osteoporosis.
  • Targeting osteoblast senescence presents promising therapeutic avenues.
  • Further research is needed to fully elucidate mechanisms and optimize treatments.
Keywords:
SASPageing‐related signalling pathwaysanti‐ageing strategiesbone microenvironmentosteoblast senescence

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